Numerous attempts have been made to show that antibodies originate in the hematopoietic system. It has been found that stimulation of the hematopoietic system by bleeding or by other methods causes an increase in the production of demonstrable antibodies. On the other hand, injury to the blood-forming organs by overexposure to x-rays or radium or by the injection of large dose of benzine or other poisons usually results in a diminished production of demonstrable antibodies. Animals thus treated are also less immune to experimental infection. Furthermore, it has been shown1 that patients with chronic diseases of the blood-forming organs (aplastic anemia, lymphatic and myelogenous leukemia) show little or no antibody response following the injection of various bacterial antigens.
While such evidence tends to show that the blood-forming organs play the chief rôle in the formation of immune bodies, other investigators emphasize the importance of the reticulo-endothelial system as the chief
CHUNG HL, REIMANN HA. ANTIBODY FORMATION IN KALA-AZAR. Arch Intern Med (Chic). 1930;46(5):782–786. doi:10.1001/archinte.1930.00140170043005