Widal, Abrami and Iancovesco1 described a test for liver dysfunction which they believe is based on an anaphylactic blood reaction. This reaction, to which they gave the name of hemoclastic crisis, manifests itself as (a) leukopenia with a relative lymphocytosis, (b) fall of blood pressure, (c) decrease in the refractometric index of the serum and (d) an increase in the coagulation time of the blood. The authors stated that these phenomena are a response of the presence of low proteins (peptones) in the general circulation. Their theory for the appearance of these products in the general circulation is that during digestion of protein the partially digested proteins which reach the liver via the portal circulation pass through and enter the general circulation when the liver is diseased. The normal liver prevents this transmission, because it has the property of arresting the low proteins (proteopexic function).
These authors offered the following
GOODMAN M, CONNERY JE. THE CORRELATION OF WIDAL'S POSTDIGESTIVE LEUKOPENIA AS A TEST FOR LIVER FUNCTION WITH THE NORMAL RHYTHM OF THE LEUKOCYTES. Arch Intern Med (Chic). 1930;46(6):1018-1025. doi:10.1001/archinte.1930.00140180119012