On the continent of Europe this subject has been investigated chiefly by Faber, Ewald, Zadek, Weinberg and others, Faber expressing as his opinion that achylia gastrica is generally preceded by a chronic gastritis. In England Hurst was the chief exponent; he also showed by means of the fractional test meal that the absence of free hydrochloric acid in pernicious anemia invariably persists throughout the whole period of digestion, whereas in other conditions, such as cancer of the stomach, it is not uncommon to find a small quantity of free acid in one or more of the fractions.
The significance of this achylia was pointed out by Castle,1 who in a series of experiments with normal gastric juice and beef muscle, administered in different ways to patients with pernicious anemia, endeavored to establish an etiologic relationship between achylia gastrica and pernicious anemia. This constant achylia and the facts concerning the familial
SNAPPER I, du PEREZ JDG. THE TREATMENT OF PERNICIOUS ANEMIA WITH DESICCATED HOG'S STOMACHPROF. I. SNAPPER, M.D. AND J. D. G. DU PREEZ, M.D. AMSTERDAM, HOLLAND. Arch Intern Med (Chic). 1931;47(5):771–789. doi:10.1001/archinte.1931.00140230098007