It is the present consensus1 that none of the current tests of the function of the liver determine accurately the functional capacity of the organ as a whole. The value of the more useful tests, such as the van den Bergh reaction, the icterus index and the Rosenthal test, is vitiated by the presence of obstructive jaundice even of slight degree, because these tests depend on the measurement of the capacity of the liver to excrete bilirubin or bromsulphalein. Yet in the presence of marked obstructive jaundice, the nonexcretory functions of the liver may remain relatively undisturbed. The more common of the so-called metabolic tests of the function of the liver, such as the determination of the tolerance for galactose and levulose, unfortunately do not give uniform results, and at best permit only of qualitative statements.
Therefore, a test that would determine more accurately the degree of functional impairment
LICHTMAN SS. CINCHOPHEN OXIDATION TEST OF THE FUNCTION OF THE HEPATIC CELLS. Arch Intern Med (Chic). 1931;48(1):98-125. doi:10.1001/archinte.1931.00150010103007