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September 1931


Author Affiliations


Arch Intern Med (Chic). 1931;48(3):446-461. doi:10.1001/archinte.1931.00150030097007

The purpose of this report is to add further data to that already recorded, in order to establish more definitely the relationship of the sugar in the blood and in the cerebrospinal fluid in health and disease. Although the cerebrospinal fluid has been the subject of chemical investigation for many years, it was not until an increase in the sugar in the spinal fluid was said to be diagnostic of epidemic encephalitis that quantitative determinations of sugar were given especial attention.

The amount of sugar in normal spinal fluid was at first determined by the examination of fluids promiscuously obtained. Some of these results, which were extremely variable, were undoubtedly influenced by the different methods of examination, while others were affected by the level of the blood sugar.

Shrewsbury and Williamson1 examined 151 fluids by the Folin-Wu method. In an attempt to throw more light on the theory that

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