In the opening paragraph of his paper on "Gastric Hemorrhage Due to Familial Telangiectasis," Boston1 stated:
A cursory survey of the literature disclosed records of 3 cases of recurrent rectal hemorrhage, one of oral bleeding and one of hematemesis which had been accompanied by cutaneous telangiectases. Wilson gave us the first recorded instance of rectal bleeding from telangiectases in 1896; Fox recorded a case in 1908; Phillips in 1908 cites the case of an extensive telangiectasis of the skin and mucous surface of the mouth with hemorrhages from the pharynx, and possibly from the stomach. Hutchison and Oliver's patient experienced recurrent rectal hemorrhage; and Pringle in describing his case alludes to recurrent attacks of vomiting blood.
Boston stated further that telangiectasia has not been considered in connection with painless hemorrhage of either gastric or rectal origin, and that the familial etiologic nature of the disease is evidenced in the
GOLDSTEIN HI. I. GOLDSTEIN'S HEREDOFAMILIAL ANGIOMATOSIS WITH RECURRING FAMILIAL HEMORRHAGES (RENDU-OSLER-WEBER'S DISEASE). Arch Intern Med (Chic). 1931;48(5_I):836-865. doi:10.1001/archinte.1931.00150050117011