[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.128.52. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
December 1931

THE USE OF AMIDOPYRINE IN RHEUMATIC FEVER

Author Affiliations

NEW YORK

From the Hospital of the Rockefeller Institute for Medical Research.

Arch Intern Med (Chic). 1931;48(6):1138-1155. doi:10.1001/archinte.1931.00150070076006
Abstract

In the treatment of patients with rheumatic fever during the past year in this hospital it has been found that amidopyrine is decidedly superior to other drugs heretofore employed, namely, sodium salicylate, acetylsalicylic acid, the ethyl ester of phenylcinchoninic acid, cinchophen and neocinchophen.1 As an adequate summary of the properties of amidopyrine is not available elsewhere, a brief review of the literature concerning it is presented as a preliminary to an account of the observations presented in this paper on rheumatic fever.

REVIEW OF THE LITERATURE  Filehne,2 in 1896 and in 1897, described the synthesis, the properties and a few preliminary therapeutic trials of an antipyretic and analgesic which he arbitrarily named "pyramidon," but which he designated more accurately as 4-di-methyl amino-antipyrine. Antipyrine, a condensation product of methyl-phenyl hydrazine and aceto-acetic ester, was first converted by Stolz,3 in 1893, into amidopyrine, or pyramidon, by substituting a di-methyl

First Page Preview View Large
First page PDF preview
First page PDF preview
×