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Article
April 1932

EFFECT OF LIGATION OF THE PAROTID DUCT ON THE CARBOHYDRATE METABOLISM OF TOTALLY DEPANCREATIZED DOGS

Author Affiliations

CHICAGO

From the Metabolic Laboratory of the Department of Physiology, Nelson Morris Institute for Medical Research, Michael Reese Hospital.

Arch Intern Med (Chic). 1932;49(4):663-665. doi:10.1001/archinte.1932.00150110126006
Abstract

In another study,1 the results of ligation of the parotid duct on the carbohydrate tolerance of normal dogs were reported. In these animals, it was found that the tolerance for dextrose, as determined by the blood sugar curve following the intravenous injection of dextrose solution, was definitely increased by ligation of the parotid ducts. As a step in the study of the mechanism of this action, the effect of ligation of the parotid duct was determined in a series of totally depancreatized dogs. Mansfeld and Schmidt2 found that after partial extirpation of the pancreas (Sandmeyer diabetes) the resulting disturbances in carbohydrate metabolism were greatly relieved by ligation of the parotid ducts. In one animal in which the entire pancreas had been removed they were unable to detect any improvement following ligation of the parotid duct. Seelig3 found that ligation of Stenson's ducts did not prevent animals from

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