April 1932


Author Affiliations

Emory University, Ga.

Arch Intern Med (Chic). 1932;49(4):709-710. doi:10.1001/archinte.1932.00150110172010

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To the Editor:  —In the January, 1932, issue of the Archives of Internal Medicine is an article entitled "Experimental Agranulocytosis," by B. M. Fried and William Dameshek.This article implies by title and indicates to the casual reader that the disease, agranulocytosis, has been produced by the intravenous injection of Bacillus pyocyaneus into rabbits.It is the purpose of this communication to correct any such impression and to call attention to the fact that the results obtained by the authors may be duplicated by a wide variety of substances, including milk, nonspecific proteins, dead and living bacteria and various types of inert, finely divided material.In the interpretation of their results, the authors evidently overlooked the fact that a pronounced temporary granulocytopenia results from the intravenous injection of any of the foregoing substances. This has long been recognized by research workers and those familiar with hematologic reactions in rabbits. Wells

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