April 1932


Arch Intern Med (Chic). 1932;49(4):710. doi:10.1001/archinte.1932.00150110173011

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To the Editor:  —In our studies on experimental agranulocytosis we used Salmonella suipestifer and not Bacillus pyocyaneus, as mentioned by Roy R. Kracke. The purpose of our studies was to determine the possible similarity between the blood picture as seen in agranulocytosis in man and that found in one form of experimental sepsis in rabbits. Our experiments were undertaken in connection with statements to the effect that human agranulocytosis is a disease sui generis. The experiments have shown that granulocytopenia may be observed in this form of experimental sepsis. However, no claims were made that the micro-organism used in our experiments was the essential cause of the disease in man or that other bacteria might not produce the same disease in the rabbit.Simultaneously with our paper in the Archives, there appeared an article by Roy R. Kracke, bearing the identical title that ours did: "The Experimental Production of Agranulocytosis"

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