My observations1 that student nurses with positive reactions to the Pirquet test present greater resistance to tuberculous infection than those whose reaction is negative, suggest the importance of cutaneous allergy in relation to immunity in tuberculosis. I have also demonstrated that the subcutaneous or intracutaneous injection of B C G vaccine, in nurses presenting negative reactions to the test, is able to produce a positive reaction within a certain time. On this account I was led to believe that vaccination with B C G exercises a protective influence against tuberculous infection. These conclusions made in 1926 are the basis for the decision to vaccinate subcutaneously with B C G the student nurses in the Oslo Kommunale Sykehus who enter on their course with negative reactions to the Pirquet test. This method of vaccination has been followed systematically in this hospital since January, 1927.
Among the approximately 120 student nurses
HEIMBECK J. IMMUNITY TO TUBERCULOSISRELATION OF CUTANEOUS ALLERGY AND RESISTANCE TO TUBERCULOUS INFECTION FOLLOWING VACCINATION WITH B C G. Arch Intern Med (Chic). 1932;49(6):957–963. doi:10.1001/archinte.1932.00150130080006