Synovial fluids show marked differences of suspension stability. Some are rendered clear by short centrifugation, while others still contain corpuscles after prolonged action of the centrifuge. This is suggestive of differences in composition, and an investigation appeared to be pertinent from a theoretical and a clinical point of view. The value of the sedimentation rate of blood corpuscles in plasma for the differential diagnosis of arthritis is limited by the interference of various factors. By simultaneous estimation in the synovial fluid, it was hoped to eliminate some nonspecific elements and to increase the diagnostic value of the sedimentation speed in arthritis. This program required a method of suspending an amount of corpuscles in synovial fluid equal to that in blood and a suitable technic for the comparative sedimentation test.
Preparation of the Suspension of Blood Corpuscles in Synovial Fluid.
—Into a graduated centrifuge tube is put 2 cc. of
KLING DH. SEDIMENTATION RATE OF BLOOD CORPUSCLES IN SYNOVIAL FLUID AND IN PLASMAMETHOD OF ESTIMATION AND SIGNIFICANCE IN ARTHRITIS. Arch Intern Med (Chic). 1932;50(3):419–434. doi:10.1001/archinte.1932.00150160070009