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Article
March 1933

HYPERPLASTIC SCLEROSIS OF THE PULMONARY ARTERY AND ARTERIOLESREPORT OF A CASE WITH DISCUSSION OF THE PATHOGENESIS

Author Affiliations

Instructor in Medicine; Demonstrator in Pathology; PHILADELPHIA

From the Department of Diseases of the Chest and the Pathological Laboratories of the Jefferson Medical College and Hospital.

Arch Intern Med (Chic). 1933;51(3):403-412. doi:10.1001/archinte.1933.00150220078005
Abstract

Sclerosis of the pulmonary artery and arterioles associated with Ayerza's syndrome occurs secondary to a variety of diseases, congenital and acquired, of the heart, lungs, pericardium, pleura and blood vessels (Miller1). Primary sclerosis developing independently of these conditions is much less frequent. The majority of the latter cases are due to syphilis (Rogers,2 Warthin,3 Arrillaga,4 Elizalda,5 Hare and Ross,6 Thomas,7 Bruce and co-workers,8 Cheney,9 Weber and Bode10 and Konstam and Turnbull11); a few to rheumatic fever (Paul12). In a smaller group the lesion is hyperplastic and noninflammatory and the etiology obscure (Rosenthal,13 Bacon and Apfelbach14).

REPORT OF CASE  G. P., a stevedore, white, aged 48, was first seen in October, 1924, complaining of a cough productive of a small amount of mucus, a feeling of constriction across the upper part of the chest and dyspnea, which had developed over a period of five years. The family

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