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Article
May 1933

CONSUMPTION OF BLOOD SUGAR BY MUSCLE IN THE NONDIABETIC AND IN THE DIABETIC STATE

Author Affiliations

With the Technical Assistance of W. H. Burrows WASHINGTON, D. C.

From the Georgetown University School of Medicine.

Arch Intern Med (Chic). 1933;51(5):800-813. doi:10.1001/archinte.1933.00150240159013
Abstract

It has been established for a number of years (Macleod and Pearce1) that the decline in blood sugar which follows complete removal of the abdominal viscera (including the liver) is the same in previously depancreatized as in normal dogs. This observation tended to support the hypothesis that the essential nature of pancreatic diabetes is not an inability of the tissues to consume dextrose. This experiment was criticized on the grounds of its unphysiologic nature and the necessity of keeping the animals under the influence of a general anesthetic. However, it was shown by Mann and Magath2 in their classic studies on liverless dogs that the decline of blood sugar following hepatectomy is speedier in diabetic dogs than in normal ones. Moreover, Mann and Magath reported an experiment in which complete pancreatectomy was accomplished in a dog which by previous operations had been subjected to a marked reduction in

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