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December 1933


Arch Intern Med (Chic). 1933;52(6):988-989. doi:10.1001/archinte.1933.00160060162016

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To the Editor:  After reading Dr. Ricketts' reply to my first letter, I am constrained to make the following further comments:1. Cahane's work, far from being "within the limits of error," is a confirmation of the work of Zunz (Compt. rend. Soc. de biol. 108:223, 1931).The rise in glutathione after the injection of insulin in Cahane's work is not from 0.6 to 2.2 mg., as stated at the end of the paragraph by Dr. Ricketts, but over ten times that amount (the sulphur coefficient of glutathione is 10.5). In the two human cases this difference amounts to 16 and 22 mg. and is of considerable importance.2. As to the production of hypoglycemia in normal persons with 50 Gm. of dextrose: In the case of Gibson and Lorimer, Dr. Ricketts omitted the important fact that this patient had spontaneous attacks of hyperglycemia with subjective symptoms. Furthermore, this patient

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