[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 1934


Author Affiliations

With a Roentgenologic Section by G. E. Vilvandré LONDON, ENGLAND

From the London Hospital and the Biochemical Department, Toronto University, Toronto, Canada.

Arch Intern Med (Chic). 1934;53(2):208-248. doi:10.1001/archinte.1934.00160080045003

Czerny,1 in 1873, first used the term "osteitis defromans" to describe softening and deformity of the tibia and fibula in a young soldier. Paget,2 however, was unaware of this when he published his classic description in 1877 and suggested the term "osteitis defromans" because of his belief in the inflammatory nature of the lesion. Since that time, Roberts and Cohen3 stated, more than three hundred cases of the disease have been described. In view of the fact that within four years we have observed thirty-four cases, it would appear that the disease is much commoner than was hitherto supposed. The increasing use of roentgenography is probably the explanation.

The present investigation, originally commenced in 1926 as an effort to ascertain the frequency of neurologic changes in osteitis deformans, expanded into a more comprehensive clinical and biochemical investigation.


Case 1.  History.—F. N., a

First Page Preview View Large
First page PDF preview
First page PDF preview