Report 1: The Anatomic and Clinical Character of Malignant Granuloma.
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This is an exhaustive study and review of all possible types of Hodgkin's disease, in an effort to place it definitely as a borderline inflammatory state, different from a purely neoplastic state, of the reticulo-endothelium. Confusion arises in the histologic picture, because the lesions show in a haphazard way all the polymorphic evolutionary and progressive changes that the mesenchymal tissue is capable of undergoing (inflammatory, fibrous and neoplastic) and follow stimulation by the virus. Even the cells of Sternberg are thought to be otherwise normal megakaryocytes. Stress is laid on the presence of eosinophils, the possible absence of the cells of Sternberg and, particularly, the presence of pruritus.
High voltage penetrating roentgen therapy produces the only remission of any duration. Suspected areas should be treated, but no prophylactic doses should be given. Superficial lesions should receive from 750 to 1,200 roentgen units, divided into daily doses, for from ten to
Congrès français de médecine, Twelfth Session, 1932.. Arch Intern Med (Chic). 1934;53(4):631. doi:10.1001/archinte.1934.00160100153012