[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.147.211.117. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
May 1934

EFFECT OF TOXEMIA ON TOLERANCE FOR DEXTROSE AND ON THE ACTION OF INSULIN

Author Affiliations

DALLAS, TEXAS

From the Department of Internal Medicine, Baylor University College of Medicine.

Arch Intern Med (Chic). 1934;53(5):689-698. doi:10.1001/archinte.1934.00160110058005
Abstract

In a previous article,1 attention was directed to the effect of toxemia on the tolerance for dextrose. Rabbits were given injections of varying doses of diphtheria toxin, and daily dextrose tolerance tests were made, 5 gm. of dextrose being used. It was shown that, as the toxemia increased from day to day, the tolerance for dextrose decreased. Some of the animals that survived as many as seven or eight days of the toxemia acquired blood sugar levels as high as 400 or 500 mg. two hours following the administration of dextrose. The exact explanation of this phenomenon is not clear. It may be observed in normal human beings who are toxic,2 but is more strikingly seen in diabetic persons who are victims of infections. One of two explanations may be offered for such an effect on dextrose tolerance: (a) an increased glycogenolysis or (b) an inhibition of glycogenesis.

First Page Preview View Large
First page PDF preview
First page PDF preview
×