That there is a distinct interrelationship between the gastric secretory mechanism and the acid-base balance of the blood has been definitely shown in the literature (Hermanns and Sakr,1 Bakaltschuk,2 Apperly and Crabtree,3 Browne and Vineberg4 and others). Hermanns and Sakr, who studied patients in whom the secretion was abnormal, reported that gastric hyperacidity is characterized by a low alkali reserve of the blood and achylia by a high reserve.
Studies of the acid-base balance that have been conducted on patients with pernicious anemia, in whom there is a complete dysfunction of the gastric glands, without exception have indicated abnormalities in the alkali reserve or in the reaction of the blood associated with this disease. Kahn and Barsky5 (1919), Gettler and Lindeman6 (1920) and Ashby7 (1925) reported a lowered alkali reserve in the majority of the cases studied, indicating acidosis, whereas, on the other hand, Barr and Peters8 (1921), Dautrebande9 (1925),
EMERSON CP, HELMER OM. REACTION (ph) AND CARBON DIOXIDE CONTENT OF THE VENOUS PLASMA IN PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1935;55(2):254-261. doi:10.1001/archinte.1935.00160200084005