October 1935


Arch Intern Med (Chic). 1935;56(4):700-709. doi:10.1001/archinte.1935.00170020074002

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This study of scillonin includes observations on 104 patients to whom the drug was given for cardiac decompensation. To these 104 patients 119 courses were given. The records for 85 patients are sufficiently complete to be used in compilations; to these patients 97 courses were given. Most of the subjects were observed at the Cook County Hospital, although some were seen at the Evanston, Wesley Memorial and Passavant Memorial Hospitals and the dispensary of Northwestern University Medical School. The drug herein reported on is a derivative of squill supplied to us in the form of tablets of 0.5 and 0.25 mg. The tablets of 0.25 mg. were assayed by Dr. H. B. Van Dyke of the University of Chicago. He reported that each tablet was equal to 1.15 of a cat unit; 1 cat unit was approximately 0.21 mg. This figure is the true average lethal dose to within 19.4

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