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December 1936


Author Affiliations

With the Collaboration of H. N. Cole, M.D.; CLEVELAND

From the Department of Pharmacology and the Department of Dermatology and Syphilology of the School of Medicine, Western Reserve University, and of the University and Cleveland City Hospitals.

Arch Intern Med (Chic). 1936;58(6):1067-1086. doi:10.1001/archinte.1936.00170160113006

An increase in the flow of urine is produced by suitable doses of any of the mercurial compounds that have been studied with this in mind, but for therapeutic use certain organic compounds are employed almost exclusively at present, largely in order to avoid other actions of mercury, which are practically inevitable with the inorganic mercurials. That the diuretic potency of the organic compounds is superior is probably often assumed, but without adequate evidence. The few quantitative clinical data are very inadequate, and quantitative comparisons on animals also are scanty, as may be seen from the review by Fourneau and Melville1 (1931). These investigators confirmed with intravenous injections into rabbits the diuretic effect for all the inorganic and organic compounds of mercury which they tried, except colloidal suspensions, with quantitative differences that appeared related to the chemical constitution. Data on animals, however, cannot be transferred quantitatively to the clinic

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