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January 1937

By-Effects in Salvarsan Therapy and Their Prevention.

Arch Intern Med (Chic). 1937;59(1):173. doi:10.1001/archinte.1937.00170170179011

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This monograph, compiled from the experience of the University Clinic of Dermatovenerology, at Copenhagen, assembles a mass of clinical data regarding arsenic intoxication during the treatment of syphilis. The entire subject, of course, is of great interest and has been widely studied; it must have been tedious work to gather together the very extensive literature which is reviewed, to assemble it properly and to add observations regarding it.

First, there is discussed the theoretical basis for arsenic intoxication; then there follow chapters on arsphenamine erythema, jaundice, albuminuria and what the author calls "paratherapeutic joint complaints." These chapters lead to a discussion as to how such uncomfortable by-effects of arsphenamine therapy may be avoided, especially by the use of a concentrated dextrose solution as a solvent for the arsphenamine. Finally the author pleads for individualization of antisyphilitic treatment; for, he claims, it is possible before treatment is begun to determine whether

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