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Article
April 1937

UNUSUAL GLYCOGEN STORAGE IN A CASE OF DIABETES MELLITUS

Author Affiliations

DURHAM, N. C.

From the Department of Pathology, the Department of Biochemistry and the Department of Medicine, Duke University School of Medicine, and Duke Hospital.

Arch Intern Med (Chic). 1937;59(4):685-690. doi:10.1001/archinte.1937.00170200127010
Abstract

In fatal cases of diabetic acidosis the stores of glycogen in the body are, as a rule, markedly depleted. The importance of the case to be described lies in the paradoxical presence of an enlarged liver containing an excessive amount of glycogen in a diabetic patient who died in acidosis.

REPORT OF CASE 

Clinical History.  —M. R., a white man aged 24, was admitted to Duke Hospital on Nov. 10, 1934, in severe diabetic acidosis. There was no family history of diabetes.In February 1930, while at work in a college laboratory, he found that his urine gave a positive reaction for sugar. This was not confirmed by the physician of the college. In September 1930 the patient began to lose weight and to have polyuria, polyphagia and polydipsia. Two months later, while he was in the college infirmary for an unrelated cause, glycosuria was again detected. His family physician

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