June 1937


Author Affiliations


From the Department of Nervous and Mental Diseases, Northwestern University Medical School.

Arch Intern Med (Chic). 1937;59(6):1000-1023. doi:10.1001/archinte.1937.00170220076005

In the widespread search for a possible relation between bodily disease and epilepsy, carbohydrate metabolism has been studied by numerous authors. The occurrence of convulsions in states of hypoglycemia either as a result of the injection of insulin or spontaneously in the course of hyperinsulinism has further focused attention on the possible disorders of this function.

One of the difficulties encountered in such a study lies in the absence of indications of dysfunction not primarily related to diabetes. Examinations of large numbers of normal subjects have been made more with the view of determining the character of metabolism not related to diabetes than of evaluating the functions of the organs concerned in carbohydrate metabolism. Therefore, what are described as normal types of curves, with arbitrarily constructed formulas, may be applicable for subjects who are not diabetic or destined to be diabetic, but they do not give any indication of what

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