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June 1937


Author Affiliations


From the Laboratory of Biochemistry, the Jefferson Hospital, and the Department of Medicine, the Jefferson Medical College.

Arch Intern Med (Chic). 1937;59(6):1045-1050. doi:10.1001/archinte.1937.00170220121008

Since Roberts1 first reported an increase in the phosphatase content of the serum of certain patients with obstructive jaundice, this phenomenon has attracted considerable attention. There still appears to be some difference of opinion regarding the clinical significance of an increase in this factor and its value in differentiating between hepatocellular and obstructive types of jaundice. As this important question can be settled only by the accumulation of observations for large numbers of patients, data obtained for fifty-three patients with jaundice are presented here for the purpose of supplementing those previously reported by other observers.

MATERIAL AND METHODS  The phosphatase content of the serum was determined by the method of Bodansky,2 blood being withdrawn after a fasting period of about fourteen hours. In our experience, based on determinations made for hospital patients, values below 7 units for adults and 15 units for children are without clinical significance. In

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