Although the experimental nephrosis induced by uranium nitrate has been studied extensively, many of the factors influencing the excretion of urinary substances in this condition are still imperfectly understood.
The present investigation was undertaken originally to demonstrate more clearly the mechanism of the glycosuria which occurs during the early stages of the nephrosis induced by uranium. Later the studies were extended to urinary substances other than sugar, and the output of nitrogen, chlorides and albumin was determined throughout the course of the nephrosis. The alterations in the excretion of the urinary substances were correlated with the changes in the concentration of some of these substances in the blood and with the anatomic alterations in the kidneys. Most of the previous work on experimental uranium nephrosis has been reviewed in the excellent monograph of MacNider;1 therefore, only the literature directly pertinent to the present report will be discussed.
MILHORAT AT, DEUEL HJ. ACUTE URANIUM NEPHROSISTHE MECHANISM OF THE GLYCOSURIA. Arch Intern Med (Chic). 1937;60(1):77–87. doi:10.1001/archinte.1937.00180010082006