By W. F. von Oettingen, M.D., Ph.D., Director of the Haskell Laboratory of Industrial Toxicology, Wilmington, Del. Cloth. Price, $4.75. Pp. 258, with 28 tables and 4 charts. Ann Arbor, Mich.: Edwards Brothers, Inc., 1936.
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This book is the second in a series of monographs of the American Chemical Society. It is an important contribution to the pharmacologic literature. It consists of a systematic description, primarily pharmacologic but also chemical, of the substances the foundations of which are the pyrrole or pyridine nucleus that have been studied for their therapeutic activity. These two nuclei, which received their original interest and stimulus from coal tar chemistry, are the structural bases for many drugs. Among the accepted synthetic preparations may be mentioned isacen, neo-iopax, metycaine, diothane, eucaine hydrochloride and homatropine. Among the accepted alkaloids of plant origin may be mentioned physostigmine, sparteine sulfate, atropine, scopolamine, cocaine and pelletierine tannate. They also form the bases for a large number of substances both synthetic and occurring naturally which are either important structural units of tissues, such as the amino-acid tryptophan, or substances which have been extensively studied pharmacologically in
Therapeutic Agents of the Pyrrole and Pyridine Group.. Arch Intern Med (Chic). 1937;60(1):176. doi:10.1001/archinte.1937.00180010181014