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Article
September 1937

LEUKEMIA WITHOUT LEUKOCYTOSIS (ALEUKEMIC MYELOSIS) AND WITHOUT SPLENOMEGALY

Author Affiliations

Assistant Professor of Medicine; Research Assistant SAN FRANCISCO

From the Department of Medicine, the University of California Medical School.

Arch Intern Med (Chic). 1937;60(3):458-473. doi:10.1001/archinte.1937.00180030075008
Abstract

It is well known that leukemia may occur without leukocytosis. In such cases the clinical picture of weakness and pallor and the varying degrees of lymphadenopathy, splenomegaly and hepatomegaly, with the blood picture of anemia and thrombopenia and the presence of myeloblasts in the stained blood film, make the diagnosis possible. The anatomic findings in the cases hitherto reported1 show a similarity to the anatomic picture in true leukemia. There is, however, relatively little to be found in the medical literature on the occurrence of leukemia without splenomegaly. In a recent review2 on leukemia it was mentioned that there are instances in which no splenic enlargement is noted. Hirschfeld3 reported four cases of leukemia without splenomegaly, Ordway and Gorham4 reported one case and Kracke and Garver5 also described one case. Recently Parkes Weber6 reported a case of aleukemic myelosis without splenic enlargement in which the condition

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