In a communication by Barker and one of us (T. S.)1 the effect of the subcutaneous administration of oxygen on experimentally induced anoxemia in dogs was discussed. The failure of the injected oxygen to alter the oxygen content or percentage of desaturation of the arterial blood and the lack of evidence of absorption of the injected oxygen indicate little therapeutic value for its use. However, favorable clinical results have frequently been reported, and the possibility that oxygen given subcutaneously may exert some indirect effect by stimulating the antibody-producing mechanism cannot be ignored, especially in view of the following report from the literature.
Lipkin, Podvalny and Grintzevic2 have reported on the effect of the subcutaneous administration of oxygen on the titer of complement and natural hemolysin for sheep red blood cells in normal dogs and on agglutinin formation in the dogs after injections of typhoid vaccine. The titers of
YOUMANS GP, SIMPSON T. EFFECT OF OXYGEN INJECTED SUBCUTANEOUSLY ON ANTIBODY FORMATION. Arch Intern Med (Chic). 1937;60(4):574-581. doi:10.1001/archinte.1937.00180040010002