December 1937


Author Affiliations


From the Gastro-Intestinal Section and the Renal Section of the Medical Clinic, the University of Pennsylvania Hospital.

Arch Intern Med (Chic). 1937;60(6):1028-1033. doi:10.1001/archinte.1937.00180060081008

Obstructive jaundice produces anatomic changes in the kidneys consisting chiefly of degeneration of the tubular epithelium, long familiar to pathologists under the name cholemic nephrosis. The resulting disturbances in renal function, although recognized by clinicians, have received relatively little recent study. In the present report are given the observations made on a group of patients with obstructive jaundice on whom tests of renal function were employed in an effort to delineate more carefully the clinical features of the renal lesion and to determine the severity and the course. The results indicate that clinically detectable jaundice is invariably associated with the appearance of rather characteristic abnormalities of the urine and frequently with decreased renal function. The evidence of the renal lesion disappears promptly as the jaundice subsides, leaving no detectable sign of residual damage.

METHODS OF STUDY  The subjects of the investigation were sixteen patients suffering from obstructive jaundice and one

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