During studies on the excretion of hippuric1 acid and xylose2 of patients with pernicious anemia the renal function was estimated by means of the urea clearance test. The apparent importance of renal function to the clinical status of the patients led us to make additional studies of the urea clearance of these and other patients with pernicious anemia.
Mosenthal3 stated that in cases of severe anemia, whether of the primary or of the secondary type, results were obtained with the test meal (Mosenthal test) which were similar in every detail to those that have been described in cases of advanced contracted kidney. He further stated that from the functional changes alone one would be warranted in considering the prognosis grave but that the cure of the severe anemia might be followed by great functional improvement. Kahn and Barsky4 found that in three cases of pernicious anemia
FOUTS PJ, HELMER OM. UREA CLEARANCE IN PERNICIOUS ANEMIA. Arch Intern Med (Chic). 1938;61(1):87-94. doi:10.1001/archinte.1938.00180070092007