The subcutaneous administration of oxygen first became popular in Europe after the introduction of a machine built by Dr. Bayeux,1 of Paris. Since then there has been much controversy as to the value of this form of therapy, but little attention has been paid to it in America and England until recently. The workers on the subject can readily be divided into two groups: first, those who believe its use to be of value, basing their conclusions on clinical observation unconfirmed by laboratory procedure, and, second, those who declare it to be useless, their conclusions being based entirely on experimental data.
One cannot deny that if clinical benefit is seen from the injection of oxygen subcutaneously, there must be some basis for its use. Workers claim benefit from its use in such divers conditions as distemper, burns, pneumonia, postoperative nausea and vomiting, heart failure, pulmonary tuberculosis, thrombosis and embolism,
SIMPSON T, BARKER MH. SUBCUTANEOUS ADMINISTRATION OF OXYGEN. Arch Intern Med (Chic). 1938;61(2):198-207. doi:10.1001/archinte.1938.00180080040004