Since the publication of the article by Hench,1 in 1933, in which it was noted that intercurrent jaundice may evoke a remission of chronic atrophic arthritis and fibrositis, we have been actively interested in the experimental production of jaundice. The observations of Hench have been confirmed by Sidel and Abrams2 and by Hench.3 We have studied three patients with atrophic arthritis in whom jaundice occurred. Jaundice occurred in two of these patients after toxic hepatitis, in one case due to neocinchophen (30 grains [2 Gm.] daily for sixteen days) and in the other case to neocinchophen (12 grains [0.8 Gm.] daily for twenty-four days) and oxo-ate B (calcium ortho-iodoxybenzoate, 15 grains [1 Gm.] daily for twenty days). In one patient no effect on the arthritis was noted (the serum bilirubin content was not determined), but the other patient, with the onset of jaundice, was relieved of pain.
THOMPSON HE, WYATT BL. EXPERIMENTALLY INDUCED JAUNDICE (HYPERBILIRUBINEMIA)REPORT OF ANIMAL EXPERIMENTATION AND OF THE PHYSIOLOGIC EFFECT OF JAUNDICE IN PATIENTS WITH ATROPHIC ARTHRITIS. Arch Intern Med (Chic). 1938;61(3):481–500. doi:10.1001/archinte.1938.00020030111007