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This is an exhaustive study of the complement fixation test for tumors. It is divided into ten chapters, each dealing with some phase of the reaction and its importance to the reaction. For one interested in working with the complement fixation test for diagnostic purposes, this monograph contains a great deal of valuable information.
The largest number of positive reactions to the complement fixation test for any one series of patients with carcinoma was only 34.2 per cent, and for some series as many as 24 per cent of the control noncancerous patients showed a positive reaction of the serum. The reactive power resides in the acetone-soluble fraction of fatty acids and particularly the cholesterol fraction. One must conclude, however, that for clinical purposes the reaction is, as yet, valueless.
Sero-Diagnostic Studies of Malignant Tumors: Experiments in Complement Fixation by Means of Lipoid Extracts.. Arch Intern Med (Chic). 1938;62(1):180. doi:10.1001/archinte.1938.00180120188012