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This interesting dissertation is based on rat experiments done at the Institute for Hygiene of the University of Copenhagen and contributes substantially to the knowledge of the abnormal physiology of the obstructive jaundice produced by cutting the ductus choledochus between ligatures. The author considers the question as to which is more important in this condition, (1) the disturbance of digestion and absorption that results from the exclusion of bile from the intestine or (2) the disturbance directly produced in the rest of the body by the bile pigments and bile salts circulating in the body fluids. His experiments confirm the suspicion, based on a thorough review of previous work, that the consequences of obstructive jaundice are primarily digestive and absorptive.
When kept on a standard diet, rats with obstructive jaundice showed no signs of avitaminosis D, and the only sign of avitaminosis A was chronic colpokeratosis. Such rats were more
Eksperimentelle studier over occlusionsicterus.. Arch Intern Med (Chic). 1938;62(4):720-721. doi:10.1001/archinte.1938.00180150176013