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The author presents a serologic method for the determination of the blood volume in man by injecting intravenously a known amount of antidiphtheric horse serum. The concentration of the diphtheria antitoxin (measured by the intracutaneous method for rabbits) is determined for the plasma obtained from a sample of blood taken five minutes later. A mean error in the measurements of the blood volume is claimed to be plus or minus 3.7 per cent. Repeated determinations of the blood volume of 25 normal men and 25 normal women were made. The blood volume of the men was 7.55 plus or minus 1.84 cc. per hundred grams of body weight and for the women 6.85 plus or minus 1.36 cc. The author feels, however, that owing to the large individual variations in blood volume, this method of determining the volume is of very limited clinical usefulness. There is an excellent review of
En metode til bestemmelse af menneskets blodmaengde ved hjaelp af difteriantitoksin.. Arch Intern Med (Chic). 1938;62(6):1095. doi:10.1001/archinte.1938.00180170195021