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Article
February 1939

DISEASES OF METABOLISM AND NUTRITIONREVIEW OF CERTAIN RECENT CONTRIBUTIONS

Author Affiliations

Fellow in Medicine, the Mayo Foundation. ROCHESTER, MINN.; SAN FRANCISCO; I. DISEASES OF METABOLISM By Dr. Wilder and Dr. Rutledge

From the Department of Medicine, the Mayo Clinic (Dr. Wilder), and Stanford University School of Medicine (Dr. Wilbur).

Arch Intern Med (Chic). 1939;63(2):356-427. doi:10.1001/archinte.1939.00180190158010
Abstract

ENDOCRINE RELATIONS IN DIABETES MELLITUS  The primary contribution of the past year to the physiology of diabetes mellitus was the demonstration by Frank George Young,1 of University College, London, that lasting diabetes can be produced in dogs by injection of anterior pituitary extract. The preliminary report appeared in August 1937; publication of satisfactory details was made in March 1938. Hyperglycemia and glycosuria had been obtained before with similar extracts by Evans and his associates2 (1932) and by others, including Houssay and his colleagues,3 but the glycosuria in their experiments was impermanent and persisted only as long as daily injections were maintained, never much longer. Such transitory glycosuria, even with hyperglycemia, does not constitute diabetes. It can be provoked in otherwise normal men or animals by overfunction of the thyroid or adrenal glands, by irritations of the central nervous system or by drugs, particularly by anesthetics. The outstanding

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