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Article
March 1939

DERMATOMYOSITIS WITH SCLERODERMA, CALCINOSIS AND RENAL ENDARTERITIS ASSOCIATED WITH FOCAL CORTICAL NECROSISREPORT OF A CASE IN WHICH THE CONDITION SIMULATED ADDISON'S DISEASE, WITH COMMENT ON METABOLIC AND PATHOLOGIC STUDIES

Author Affiliations

BOSTON

From the Medical Clinic, the Laboratory of Pathology and the Laboratory of Bacteriology of the Massachusetts General Hospital, and from the Fatigue Laboratory, Harvard University.

Arch Intern Med (Chic). 1939;63(3):476-496. doi:10.1001/archinte.1939.00180200045005
Abstract

The clinical similarity between Addison's disease and the syndrome recognized as dermatomyositis with scleroderma may be marked. Confusion regarding the differential diagnosis is likely and has been discussed by Osler,1 Winfield,2 Boardman,3 Longcope,4 Rowntree and Snell,5 Brown and his associates,6 Howard7 and others. The coexistence of these two diseases must be extremely uncommon, and the contemporary literature contains few reliable reports. Lewin and Heller8 in a review of 508 cases of scleroderma reported before 1895 noted that the dual diagnosis had been made in only 4. Osier1 reviewed these cases and did not consider that any of the patients had Addison's disease. In 1908 Lichtwitz9 reported a single case in which the two diseases coexisted clinically; the observation was confirmed at autopsy. Recently Leriche, Jung and De Bakey10 reported the occurrence of Addison's disease in a patient under treatment for scleroderma. Autopsy was not performed, however, and

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