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Article
June 1939

EXCRETION OF ASCORBIC ACID IN RELATION TO SATURATION AND UTILIZATIONWITH SOME DIAGNOSTIC IMPLICATIONS

Author Affiliations

CHICAGO

From the Department of Medicine, University of Illinois College of Medicine.

Arch Intern Med (Chic). 1939;63(6):1095-1116. doi:10.1001/archinte.1939.00180230080006
Abstract

In the past few years numerous reports have appeared in the literature dealing with the metabolism of ascorbic acid in man. These studies made use of the Harris-Ray1 modification of the Tillman method of titrating for this substance in the urine and the Farmer-Abt2 method for its detection in blood plasma. Several general conceptions were evolved from these studies:

  1. Ascorbic acid is excreted in the urine in its reduced state in almost all persons, the exact quantity depending on the amount of intake, but the minimal normal amount is considered to be around 20 mg. per twenty-four hours.3

  2. Reduced ascorbic acid is found in the blood stream of normally nourished persons; the concentration of this is 0.7 to 0.9 mg. per hundred cubic centimeters of plasma or higher.4

  3. Ascorbic acid is stored in almost all of the tissues of the body,5 and when these body stores are filled

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