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Article
September 1939

EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMYXII. DIETS CONTAINING DRIED EXTRACTED MEAT

Author Affiliations

UNIVERSITY, VA.

From the Laboratory of Physiological Chemistry, the University of Virginia.

Arch Intern Med (Chic). 1939;64(3):526-541. doi:10.1001/archinte.1939.00190030119009
Abstract

The effect of diets containing varying concentrations of dried whole beef muscle on the intact, the unilaterally nephrectomized and the partially nephrectomized rat has been dealt with in a previous paper.1 The present report is concerned with the effect of feeding diets containing dried extracted beef muscle on the blood pressure, heart weight, kidney weight and renal function of intact, unilaterally nephrectomized and partially nephrectomized rats.

EXPERIMENTAL METHODS  The experimental procedures have been described in previous papers.1 Briefly, they are as follows: Partial nephrectomy involved the removal of 80 to 90 per cent of total kidney tissue by a two stage operation; blood pressure readings were obtained by cannulation of the carotid artery; urine was collected for the concentration test for twenty-four hours from the rats deprived of food and water, and a modified urea clearance test of Addis1 was used for determining renal function.The five

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