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Article
December 1939

INTERCAPILLARY GLOMERULOSCLEROSISA SYNDROME OF DIABETES, HYPERTENSION AND ALBUMINURIA

Author Affiliations

NEW HAVEN, CONN.

From the Department of Internal Medicine, Yale University School of Medicine, and the Medical Service of the New Haven Hospital.

Arch Intern Med (Chic). 1939;64(6):1252-1264. doi:10.1001/archinte.1939.00190060121008
Abstract

In 1936, Kimmelstiel and Wilson1 reported the pathologic observations in a group of 8 cases of a peculiar renal lesion to which they gave the name intercapillary glomerulosclerosis. On reviewing the clinical records of the cases they found that the observations fell into a fairly well defined symptom complex, consisting of diabetes, albuminuria, hypertension, retinal vascular changes, a more or less well developed nephrotic syndrome and some degree of renal insufficiency. Anson,2 in 1938, published a study of the kidneys in the last 900 autopsies at the Hospital of the Medical College of Virginia; he observed 6 cases which satisfied the pathologic criteria proposed by Kimmelstiel and Wilson. Clinically the same features were present as in those of the latter workers, except that the nephrotic syndrome was present in only 2 instances. Neither of these groups of cases was completely studied medically, since a number of the patients

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