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Article
May 1940

SULFANILAMIDE IN TREATMENT OF INFECTIONS OF THE URINARY TRACT DUE TO BACILLUS COLI

Author Affiliations

BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Arch Intern Med (Chic). 1940;65(5):933-956. doi:10.1001/archinte.1940.00190110062006
Abstract

It is common knowledge that once the colon bacillus leaves its normal habitat it sets up inflammation and causes acute or chronic disease in different organs. The two most frequent locations for such disease are the biliary and the urinary tract. In the urinary tract the colon bacillus finds an environment that is favorable for its growth. It would appear that the factors which permit the survival and growth of the colon bacillus in the urinary tract are (1) conditions which cause stasis of the urine and (2) the chemical composition and reaction of the urine.

In the treatment of such infections of the urinary tract two methods are in general use: (1) those which relieve conditions that favor stasis of urine and (2) those which change the reaction and chemical composition of the urine so that the organisms have difficulty in surviving.

To relieve stasis, obstructions to the free

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