Our use of an aluminum phosphate gel in the therapy of peptic ulcer resulted from observations on the effect of aluminum hydroxide gel on the absorption of phosphates from the intestine. In a publication1 on the effect of aluminum hydroxide gel on the well-being and longevity of Mann-Williamson dogs, Fauley, Ivy, Terry and Bradley suggested that the unfavorable effects of this chemical in such animals might be due to an interference with the absorption of phosphates. The present report (a) includes data which demonstrate that aluminum hydroxide gel interferes with phosphate absorption and (b) presents the results of the use of aluminum phosphate gel in the treatment of experimental and clinical peptic ulcer.
Experimental ulcers were produced in Mann-Williamson dogs. The preparation of such an animal includes performing a gastrojejunostomy and diverting the pancreatic juice and bile into the terminal portion of the ileum (last 20 to 25 cm.).
FAULEY GB, FREEMAN S, IVY AC, ATKINSON AJ, WIGODSKY HS. ALUMINUM PHOSPHATE IN THE THERAPY OF PEPTIC ULCEREFFECT OF ALUMINUM HYDROXIDE ON PHOSPHATE ABSORPTION. Arch Intern Med (Chic). 1941;67(3):563-578. doi:10.1001/archinte.1941.00200030093006