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Article
March 1941

DIASTATIC ACTIVITY OF HUMAN BLOOD

Author Affiliations

ST. LOUIS

From the laboratory of the Jewish Hospital.

Arch Intern Med (Chic). 1941;67(3):665-679. doi:10.1001/archinte.1941.00200030195015
Abstract

The presence of diastase1 in human blood was first noted in 18462 and subsequently the enzyme was found to be a normal constituent of mammalian blood in general. In 1863 the enzyme was shown to be present also in urine, and its origin was traced to the blood.3 Eventually diastase was detected in lymph,4 in pericardial fluid4b and in feces.5 Hepatic bile is almost completely devoid of diastase,6 but the enzyme can be detected in the bile when the diastase content of blood is greatly increased by ligation of the pancreatic ducts.7 Bile from the common bile duct and the gallbladder may contain appreciable amounts of diastase as the result of pancreatic reflux.8 Assertions that measurable amounts of diastase are present in the cerebrospinal fluid,9 the liver and the kidneys10 are open to doubt. In this laboratory it was not possible to detect diastase in the

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