November 1941


Author Affiliations

New York

Richmond Hill, N. Y.; Chemical Laboratory, Department of Surgery, Columbia University. Endo Products.

Arch Intern Med (Chic). 1941;68(5):1037-1038. doi:10.1001/archinte.1941.00200110189010

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To the Editor:  —Some of the theories of gallstone formation are concerned with the maintenance of the solution of cholesterol in bile. About eleven years ago E. L. Walsh and A. C. Ivy (Observations on the Etiology of Gallstones, Ann. Int. Med.4:134 [Aug.] 1930) published results that seemed to indicate that the fatty acids or soaps in the bile exerted a more pronounced effect on cholesterol solubility than the bile acids. The former are in greater concentration in dog bile than in human bile, and this, according to Walsh and Ivy, accounts for the rarity of cholelithiasis in dogs and its frequency in human beings.Later work by Dolkart, Jones and Brown from the same laboratory (Chemical Factors Concerned in the Formation of Gallstones, Arch. Int. Med. 62:618 [Oct.] 1938) supports this idea. The solubility of gallstone tablets was tested in a bile fraction that was tested in

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