April 1942


Arch Intern Med (Chic). 1942;69(4):715-716. doi:10.1001/archinte.1942.00200160166012

Some of the most efficient therapeutic agents have undesirable side reactions even when judiciously employed. The sulfanilamide compounds are an example, although some reduction in the incidence of reactions has accompanied increased care in dosage and administration. Reactions following sulfanilamide therapy cannot apparently be altogether prevented. Now a group of investigators1 claim to have devised a comparatively simple formula which is effective experimentally in reducing the toxic possibilities of sulfanilamide, sulfapyridine (2-[paraaminobenzenesulfonamidoj-pyridine) and sulfathiazole (2-[paraaminobenzenesulfonamidoj-thiazole) and yet does not result in a decrease in therapeutic efficacy.

The work which is reported in this issue of the Archives appears to be based on the assumption that detoxication in the body is obtained by oxidation, reduction and conjugation and that the principal compounds involved in this process are aminoacetic acid, choline, cystine, glucuronic acid, glutamine, sulfates, acetates and ornithine. Toxicity of sulfanilamide is ascribed to a sudden withdrawal of

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