May 1942


Author Affiliations

Chicago.; Department of Physiology and Pharmacology, Northwestern University Medical School.

Arch Intern Med (Chic). 1942;69(5):927-928. doi:10.1001/archinte.1942.00200170209012

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To the Editor:  —In the November issue (Chemical Factors in the Formation of Gallstones, Arch. Int. Med.65:1037, 1941) Dr. Louis Bauman and Dr. Joseph T. Bashour questioned certain aspects of the investigations reported by us regarding the solubility of the cholesterol in gallstones. We should like to clarify the points raised in their discussion.We reiterate that our experiments as well as those of Walsh and Ivy have shown that the solvent capacity of bile for cholesterol lies to a great extent, although not exclusively, in what has been termed the saponifiable, or "fatty acid," fraction of bile. By the latter term is meant the material obtained by acidifying and extracting with a suitable fat solvent the portion of the bile that has been treated with alcoholic potassium hydroxide and from which all of the nonsaponifiable matter has been removed. Obviously, bile salts are not present in this fraction, designated

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