June 1942


Author Affiliations


From the Lasker Foundation for Medical Research and the Department of Medicine of the University of Chicago.

Arch Intern Med (Chic). 1942;69(6):1005-1009. doi:10.1001/archinte.1942.00200180076006

Meakins and Long1 were the first to study intermediates of tissue carbohydrate metabolism in heart disease. In 1927 they showed a marked and proportional increase in blood lactic acid in patients with heart failure. The validity of these results was subsequently both confirmed2 and denied.3 The importance of lactic acid as the center of carbohydrate metabolism has since been overshadowed by that of pyruvic acid, and recently even more interest has attached itself to pyruvic acid because of Peters'4 discovery that the presence of vitamin B1 is necessary for its oxidation.

In 1937 Taylor, Weiss and Wilkins5 attempted estimations of blood pyruvic acid on persons with all types of disease by measuring the blood bisulfite-binding substances and showed a rise of these in subjects with failing hearts. This method of pyruvate estimation has since been shown, however, to be nonspecific and inaccurate.6 This present work makes use

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