The practice of transfusing blood of group O (IV Moss) to persons belonging to any of the various blood groups is based on the assumption that cells of group O are not hemolyzed or agglutinated by any normal human plasma. The concept of a universal donor as developed by Ottenberg about thirty years ago has had considerable practical application, supported mainly on the theory that the dilution of a donor's blood and the absorption of the isoagglutinins anti-A and anti-B in a patient's plasma and tissue cells would tend to prevent any significant hemolysis or agglutination.
While some institutions with large transfusion services are using blood from universal donors without observing an undue reaction rate, hemolytic and other reactions have been reported after transfusion of such blood. They may vary through all degrees of severity, and a good number of representative cases have been reported in the literature. In an
KLENDSHOJ NC, McNEIL C, SWANSON P, WITEBSKY E. TRANSFUSION OF CONDITIONED UNIVERSAL BLOODCLINICAL OBSERVATIONS. Arch Intern Med (Chic). 1942;70(1):1–10. doi:10.1001/archinte.1942.00200190011001