The importance of hyperacidity of the gastric juice as a factor in the causation of duodenal ulcer and of chronic dyspeptic symptoms is widely recognized. Most forms of treatment aim at controlling hyperacidity by means of repeated chemical neutralization or by surgical intervention. The occurrence of gastrojejunal ulceration following surgical treatment, however, suggested that other methods for the control of gastric acidity might be tried, and to this end a study was made of the effects of irradiation of the gastric mucosa by radium.
As a preliminary 3 elderly patients with a long history of duodenal ulceration were selected for trial, and later, as the results were promising, a number of younger patients with hyperacidity and a shorter history also underwent treatment. In all cases gastric function was studied before and after the use of radium. Either two 25 mg. needles or four 10 mg. needles of radium were
JENKINS JA, McGEORGE M. CONTROL BY RADIUM FOR GASTRIC ACIDITY. Arch Intern Med (Chic). 1942;70(5):714-721. doi:10.1001/archinte.1942.00200230027002